Ciwon koda na yau da kullun (CKD) marasa lafiya sukan sami hyperphosphatemia, kuma hyperphosphatemia na dogon lokaci na iya haifar da matsaloli masu tsanani kamar hyperparathyroidism na biyu, osteodystrophy na koda, da cututtukan zuciya. Sarrafa matakan phosphorus na jini wani muhimmin sashi ne na kula da marasa lafiya na CKD, kuma phosphate binders sune magungunan ginshiƙan don maganin hyperphosphatemia. A cikin 'yan shekarun nan,lanthanum carbonate, a matsayin sabon nau'in nau'in nau'in nau'in calcium da kuma wanda ba aluminum phosphate ba, sannu a hankali ya shiga fagen hangen nesa na mutane kuma ya fara "gasa" tare da haɗin gwiwar phosphate na gargajiya.
Abubuwan da ake amfani da su "da" na al'ada na phosphate masu ɗaure
Abubuwan haɗin phosphate na al'ada sun haɗa da abubuwan haɗin phosphate masu ɗauke da alli (kamar calcium carbonate da calcium acetate) da aluminum mai ɗauke da phosphate binders (irin su aluminum hydroxide). Suna haɗawa da phosphates a cikin abinci don samar da mahadi marasa narkewa, wanda hakan zai rage sha na phosphorus na hanji.
Calcium-dauke da phosphate binders: Ƙananan farashi da tabbataccen sakamako na rage phosphorus, amma amfani da dogon lokaci na iya haifar da hypercalcemia kuma yana ƙara haɗarin ƙwayar jijiyoyin jini.
Aluminum-dauke da phosphorus binders: Ƙarfin rage tasirin phosphorus, amma tarin aluminum yana da guba sosai kuma yana iya haifar da cututtukan ƙasusuwa da ke da alaƙa da aluminum, kuma a halin yanzu ba a yi amfani da su ba.
Lanthanum carbonate: Tashin sabon shiga, tare da fa'idodi masu mahimmanci
Lanthanum carbonate carbonate ne na ƙarancin ƙarfe na ƙasa mai ƙarancin lanthanum, tare da na'urar ɗaurin phosphorus na musamman. Yana sakin ions na lanthanum a cikin yanayin acidic na fili na narkewa kuma yana samar da lanthanum phosphate mai saurin narkewa tare da phosphate, don haka yana hana shan phosphorus.
Taƙaitaccen gabatarwar lanthanum carbonate
| Sunan samfur | Lanthanum carbonate |
| Formula | La2 (CO3) 3.xH2O |
| CAS No. | 6487-39-4 |
| Nauyin Kwayoyin Halitta | 457.85 |
| Yawan yawa | 2.6 g/cm 3 |
| Wurin narkewa | N/A |
| Bayyanar | Farin lu'u-lu'u |
| Solubility | Mai narkewa a cikin ruwa, matsakaici mai narkewa a cikin acid mai ƙarfi mai ƙarfi |
| Kwanciyar hankali | Sauƙi hygroscopic |
Idan aka kwatanta da na al'ada na phosphorus, lanthanum carbonate yana da fa'idodi masu zuwa:
Babu alli da aluminum, mafi girma aminci: Guji haɗarin hypercalcemia da guba na aluminium, musamman ga marasa lafiya tare da magani na dogon lokaci da haɗarin ƙwayar ƙwayar cuta.
Ƙarfin daurin phosphorus mai ƙarfi, tasirin rage phosphorus mai mahimmanci: Lanthanum carbonate na iya ɗaure phosphorus da kyau a cikin kewayon pH mai faɗi, kuma ikon ɗaurinsa ya fi ƙarfin daurin phosphorus na gargajiya.
Ƙananan halayen halayen ciki na ciki, kyakkyawar yarda da haƙuri: Lanthanum carbonate yana da kyau, yana da sauƙin ɗauka, yana da ɗan haushi na gastrointestinal, kuma marasa lafiya sun fi dacewa su bi magani na dogon lokaci.
Shaidar bincike na asibiti: Lanthanum carbonate yana aiki da kyau
Yawancin nazarin asibiti sun tabbatar da tasiri da amincin lanthanum carbonate a cikin marasa lafiya na CKD. Nazarin ya nuna cewa lanthanum carbonate ba kasa da ko ma fi na gargajiya phosphate binders a rage jini matakan phosphorus, da kuma iya yadda ya kamata sarrafa iPTH matakan da inganta kashi metabolism Manuniya. Bugu da ƙari, amincin magani na dogon lokaci tare da lanthanum carbonate yana da kyau, kuma ba a sami tarin lanthanum na zahiri da halayen guba ba.
Jiyya na mutum ɗaya: Zaɓi mafi kyawun shirin ga majiyyaci
Ko da yake lanthanum carbonate yana da fa'idodi da yawa, ba yana nufin cewa zai iya maye gurbin ma'aunin phosphate na gargajiya gaba ɗaya ba. Kowace miyagun ƙwayoyi yana da alamunta da contraindications, kuma tsarin kulawa ya kamata ya kasance daidai da ƙayyadaddun halin da ake ciki na mai haƙuri.
Lanthanum carbonate ya fi dacewa da marasa lafiya masu zuwa:
Marasa lafiya tare da hypercalcemia ko haɗarin hypercalcemia
Marasa lafiya tare da ƙwayar ƙwayar cuta ko haɗarin ƙwayar ƙwayar cuta
Marasa lafiya da rashin haƙuri ko rashin inganci na masu ɗaure phosphate na gargajiya
Har ila yau ana iya amfani da masu ɗaure phosphate na gargajiya ga marasa lafiya masu zuwa:
Marasa lafiya da ƙayyadaddun yanayin tattalin arziki
Marasa lafiya waɗanda ke da rashin haƙuri ko rashin haƙuri na lanthanum carbonate
Neman zuwa gaba: Lanthanum carbonate yana da makoma mai haske
Tare da zurfafa bincike na asibiti da kuma tarawar ƙwarewar asibiti, matsayi na lanthanum carbonate a cikin maganin hyperphosphatemia a cikin marasa lafiya na CKD zai ci gaba da ingantawa. A nan gaba, ana sa ran lanthanum carbonate zai zama mai ɗaure phosphate na farko, yana kawo labarai mai daɗi ga ƙarin marasa lafiya na CKD.
Lokacin aikawa: Maris 25-2025